ADNCD
ADNCD
ANTI-DIABETIC NATURAL COMPOUNDS DATABASE
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AMPK activators
CD38 Expression Downregulators
DPP-IV Inhibitors
Enzyme Inhibitors
GLP-1 agonists
GLUT4 activators
KATP channel Inhibitors
Natural compounds for other diabetes related issues
Natural compounds improving expression of Insulin Receptor
Natural compounds improving Glucose Uptake
Natural compounds improving Insulin Secretion
Natural compounds improving Insulin Sensitivity
Natural compounds modifying the level of Akt phosphorylation
Natural compounds reducing Diabetic Nephropathy/Diabetic Neuropathy/Diabetic Cataract/Cardio-vascular Complications
Natural compounds showing Hypoglycemic activity/Anti-diabetic activity
Natural compounds showing Insulin Mimetic Activity
Natural compounds showing Insulinotrophic effect
PPAR- γ, α and δ activation
SGLT2 inhibitors
Anti-diabetic mode of action:
Insulin Secretagogues
Natural compounds improving Insulin Secretion
S.No.
Compound
Reference
Physicochemical Properties and Toxicity Risks
1
Beta-sitosterol
Ng et al., 1986
Properties and Risk Assessment
2
Tormentic Acid
Villar et al., 1986
Ivorra et al.1989
Properties and Risk Assessment
3
Chlorogenic Acid
Qa'dan et al., 2009
Properties and Risk Assessment
4
Leucodelphinidin
Geetha et al., 1994
Properties and Risk Assessment
5
Lupanine
Wiedemann et al., 2015
Properties and Risk Assessment
6
Salidroside
Li et al., 2011
Properties and Risk Assessment
7
Sparteine
Gurrola-Diaz et al., 2008
Properties and Risk Assessment
8
Stigmasterol
Thakur et al., 2012
Properties and Risk Assessment
9
Rutin
Kappel et al., 2013
Properties and Risk Assessment
10
Epigallocatechin Gallate
Ortsater et al., 2012
Properties and Risk Assessment
11
Resveratrol
Szkudelski and Szkudelska, 2015
Properties and Risk Assessment
12
Ginsenoside Rh2
Lee et al., 2006
Properties and Risk Assessment
13
Trigonelline
Zhou et al., 2012
Properties and Risk Assessment
14
Oleanoic acid
Dubey et al., 2013
Teodoro et al., 2008
Properties and Risk Assessment
15
Estrogen
Magdalena et al., 2015
Properties and Risk Assessment
16
Conophylline
Kawakami et al., 2010
Kojima et al., 2006
Properties and Risk Assessment
17
4-hydroxyisoleucine
Ajabnoor and Tilmisany, 1988
Broca et al., 1999
Properties and Risk Assessment
18
Myristicin
Somani et al., 2008
Properties and Risk Assessment
19
Ginsenoside Rg3
Park et al., 2008
Properties and Risk Assessment
20
Eremanthin
Eliza et al., 2009
Properties and Risk Assessment
21
Nuciferine
Nguyen et al., 2012
Properties and Risk Assessment
22
Roseoside
Frankish et al., 2010
Properties and Risk Assessment
23
Catechin
Nagao et al., 2008
Properties and Risk Assessment
24
Forskolin
Hill et al., 1987
Properties and Risk Assessment
25
Yohimbine
Abdel-Zaher et al., 2001
Properties and Risk Assessment
26
Cinchonain Ib
Qadan et al., 2009
Properties and Risk Assessment
27
Epicatechin
Hii and Howell, 1984
Properties and Risk Assessment
28
Beta-sitosterol 3-D-glucoside
Ivorra et al., 1990
Properties and Risk Assessment
29
S-allyl cysteine Sulfoxide
Augusti and Sheela, 1996
Properties and Risk Assessment
30
Shogaol
Li et al., 2012
Properties and Risk Assessment
31
Quinine
McLaren and Jones, 2010
Properties and Risk Assessment
32
Glyceollin I
Park et al., 2010
Properties and Risk Assessment
33
Glyceollin II
Park et al., 2010
Properties and Risk Assessment
34
Glyceollin III
Park et al., 2010
Properties and Risk Assessment
35
Chicoric acid
Tousch et al., 2008
Properties and Risk Assessment
36
Allicin
Mathew and Augusti, 1973
Properties and Risk Assessment
37
Lupeol
Gupta et al., 2011
Gupta et al., 2012
Properties and Risk Assessment
38
Mangiferin
Sellamuthu et al., 2013
Properties and Risk Assessment
39
Estrogen
Ahmed and Hassanein, 2012
Properties and Risk Assessment
40
p-coumaric acid
Amalan and Vijayakumar, 2015
Properties and Risk Assessment
41
Enhydrin
Genta et al., 2010
Properties and Risk Assessment
42
Thymol
Manzari-Tavakoli et al., 2013
Properties and Risk Assessment
43
Arachidonic acid
Metz, 1988
Properties and Risk Assessment
44
Curcumin
Wickenberg et al., 2010
Properties and Risk Assessment
45
6-Gingerol
Chakraborty et al., 2012
Properties and Risk Assessment
46
Kinsenoside
Zhang et al., 2007
Properties and Risk Assessment