ADNCD
   
 
 
Select Mode of Action
Anti-diabetic mode of action: Alpha-glucosidase/Amylase/ Aldose reductase/Lactase/ Maltase/Sucrase/Glycohydrolases inhibitors
Enzyme Inhibitors
S.No. Compound Reference Inhibited Physicochemical Properties and Toxicity Risks
1 KolavironIwu et al., 2011Aldose reductase Properties and Risk Assessment
2 ScopoletinKim et al., 2013Aldose reductase Properties and Risk Assessment
3 GossypolDeck et al., 1999Aldose reductase Properties and Risk Assessment
4 CitronellolJagdale et al., 2015Aldose reductase Properties and Risk Assessment
5 Miglitol(Known Drug)Sels et al., 1999Alpha-glucosidase Properties and Risk Assessment
6 Acarbose(Known Drug)Martin and Montgomery, 1996Alpha-glucosidase Properties and Risk Assessment
7 Luteolin-7-O-glucosideKim et al., 2000Alpha-glucosidase Properties and Risk Assessment
8 LuteolinKim et al., 2000Alpha-glucosidase Properties and Risk Assessment
9 AmentoflavoneKim et al., 2000Alpha-glucosidase Properties and Risk Assessment
10 DiadzeinKim et al., 2000Alpha-glucosidase Properties and Risk Assessment
11 Caffeic acidOboh et al., 2015Alpha-glucosidase Properties and Risk Assessment
12 LupeolSiddique and Saleem, 2011Alpha-glucosidase Properties and Risk Assessment
13 Diphlorethohydroxy-carmalolHeo et al., 2009Alpha-glucosidase Properties and Risk Assessment
14 Alpha-HomonojirimycinKim et al., 1999Alpha-glucosidase Properties and Risk Assessment
15 DaucosterolAsghari et al., 2015Alpha-glucosidase Properties and Risk Assessment
16 BerberinYin et al., 2012Alpha-glucosidase Properties and Risk Assessment
17 SalacinolMorikawa et al., 2015Alpha-glucosidase Properties and Risk Assessment
18 2,5-Dihydroxymethyl-3,4-DihydroxypyrrolidineCarreiro et al., 2014Alpha-glucosidase Properties and Risk Assessment
19 KotalanolXie et al., 2011Alpha-glucosidase Properties and Risk Assessment
20 NeoponkoranolXie et al., 2011Alpha-glucosidase Properties and Risk Assessment
21 NeosalaprinolXie et al., 2011Alpha-glucosidase Properties and Risk Assessment
22 Nummularine-RChoudhary et al., 2011Alpha-glucosidase Properties and Risk Assessment
23 Nummularin-CChoudhary et al., 2011Alpha-glucosidase Properties and Risk Assessment
24 Hemsine-AChoudhary et al., 2011Alpha-glucosidase Properties and Risk Assessment
25 Iriflophenone 2-O-a-L-rhamnopyranosideFeng et al., 2011Alpha-glucosidase Properties and Risk Assessment
26 2,4,6-tribromophenolKim et al., 2011Alpha-glucosidase Properties and Risk Assessment
27 2,4-dibromophenolKim et al., 2011Alpha-glucosidase Properties and Risk Assessment
28 ProcyanidinSchafer and Hogger, 2007Alpha-glucosidase Properties and Risk Assessment
29 SerotoninTakahashi and Miyazawa, 2012Alpha-glucosidase Properties and Risk Assessment
30 Butyl-isobutyl-phthalateBu et al., 2010Alpha-glucosidase Properties and Risk Assessment
31 Aloeresin AJong-Anurakkun et al., 2008Alpha-glucosidase Properties and Risk Assessment
32 Miglitol(Known Drug)Reuser and Wisselaar, 1994Alpha-glucosidase Properties and Risk Assessment
33 Acarbose(Known Drug)Goldstein and Muller-Wieland, 2008Alpha-glucosidase Properties and Risk Assessment
34 HydnocarpinReddy et al., 2013Alpha-glucosidase Properties and Risk Assessment
35 VasicineGao et al., 2007Alpha-glucosidase Properties and Risk Assessment
36 VasicinolGao et al., 2007Alpha-glucosidase Properties and Risk Assessment
37 MyricetinKang et al., 2015Alpha-glucosidase Properties and Risk Assessment
38 DiosgeninGhosh et al., 2014Alpha-glucosidase Properties and Risk Assessment
39 QuercetinLi et al., 2009Alpha-glucosidase Properties and Risk Assessment
40 TurmericLekshmi et al., 2012Alpha-glucosidase Properties and Risk Assessment
41 (2S)-Euchrenone a7Yang et al., 2012Alpha-glucosidase Properties and Risk Assessment
42 ChalcomoracinYang et al., 2012Alpha-glucosidase Properties and Risk Assessment
43 Moracin CYang et al., 2012Alpha-glucosidase Properties and Risk Assessment
44 Moracin DYang et al., 2012Alpha-glucosidase Properties and Risk Assessment
45 Moracin NYang et al., 2012Alpha-glucosidase Properties and Risk Assessment
46 5-O-caffeoylquinic acidIshikawa et al., 2007Alpha-glucosidase Properties and Risk Assessment
47 Chebulagic acidPham et al., 2014Alpha-glucosidase Properties and Risk Assessment
48 NarcissinPham et al., 2014Alpha-glucosidase Properties and Risk Assessment
49 CorilaginPham et al., 2014 Honma et al., 2010Alpha-glucosidase Properties and Risk Assessment
50 Macatannin BMaria et al., 2010Alpha-glucosidase Properties and Risk Assessment
51 Mallotinic acidMaria et al., 2010Alpha-glucosidase Properties and Risk Assessment
52 Cyanidin-3-galactosideAdisakwattana et al., 2009 Akkarachiyasit et al., 2010Alpha-glucosidase Properties and Risk Assessment
53 Luteolin-7-O-glucosideKim et al., 2000Amylase Properties and Risk Assessment
54 LuteolinKim et al., 2000Amylase Properties and Risk Assessment
55 AmentoflavoneKim et al., 2000Amylase Properties and Risk Assessment
56 DiadzeinKim et al., 2000Amylase Properties and Risk Assessment
57 Ellagic acidPinto et al., 2010 Amylase Properties and Risk Assessment
58 Caffeic acidOboh et al., 2015Amylase Properties and Risk Assessment
59 Diphlorethohydroxy-carmalolHeo et al., 2009Amylase Properties and Risk Assessment
60 Gallic acidGunawan-Puteri et al., 2012Amylase Properties and Risk Assessment
61 MahanimbineDineshkumar et al., 2010Amylase Properties and Risk Assessment
62 Acarbose(Known Drug)Goldstein and Muller-Wieland, 2008Amylase Properties and Risk Assessment
63 FukugetinYunfang et al., 2014Amylase Properties and Risk Assessment
64 DiosgeninGhosh et al., 2014Amylase Properties and Risk Assessment
65 TurmericLekshmi et al., 2012Amylase Properties and Risk Assessment
66 CorilaginGunawan-Puteri et al., 2012Amylase Properties and Risk Assessment
67 Macatannin BGunawan-Puteri et al., 2012Amylase Properties and Risk Assessment
68 Cyanidin-3-galactosideAkkarachiyasit et al., 2010Amylase Properties and Risk Assessment
69 CastanospermineRhinehart et al., 1987 Robinson et al., 1989Glycohydrolase Properties and Risk Assessment
70 DiosgeninMcAnuff-Harding et al., 2006Lactase Properties and Risk Assessment
71 Miglitol(Known Drug)Goldstein and Muller-Wieland, 2008Maltase Properties and Risk Assessment
72 DiosgeninMcAnuff-Harding et al., 2006Maltase Properties and Risk Assessment
73 CastanospermineRhinehart et al., 1987 Robinson et al., 1989Sucrase Properties and Risk Assessment
74 VasicineGao et al., 2007Sucrase Properties and Risk Assessment
75 VasicinolGao et al., 2007Sucrase Properties and Risk Assessment
76 Miglitol(Known Drug)Goldstein and Muller-Wieland, 2008Sucrase Properties and Risk Assessment