Classification of different anti-diabetic mechanism of actions of natural compounds
S.No. Anti-diabetic natural compounds Mode of action
1 Natural compounds modifying the level of Akt phosphorylation Akt phosphorylation
2 Enzyme Inhibitors Alpha-glucosidase/Amylase/ Aldose reductase/Lactase/ Maltase/Sucrase/Glycohydrolases inhibitors
3 CD38 Expression Downregulators Downregulation of Cluster of Differentiation 38 expression
4 GLUT4 activators Glucose Transporter Type 4 activation
5 Natural compounds showing Hypoglycemic activity/Anti-diabetic activity Hypoglycemic /Anti-diabetic activity
6 Natural compounds improving Glucose Uptake Improving Glucose Uptake
7 Natural compounds reducing Diabetic Nephropathy/Diabetic Neuropathy/Diabetic Cataract/Cardio-vascular Complications Improving diabetes related disorders
8 GLP-1 agonists Increases GLP-1 level (Glucagon-like Peptide-1 level)
9 DPP-IV Inhibitors
(Dipeptidyl Peptidase-IV inhibitors)
Increases GLP-1 level (Glucagon-like Peptide-1 level)
10 Natural compounds improving expression of Insulin Receptor Increasing Insulin Receptor expression
11 Natural compounds showing Insulin Mimetic Activity Insulin Mimetic Activity
12 KATP channel Inhibitors
(ATP-Sensitive Potassium Channel Inhibitors)
Insulin Secretagogues
13 Natural compounds improving Insulin Secretion Insulin Secretagogues
14 AMPK activators
(Adenosine Monophosphate-Activated Protein Kinase activators)
Insulin Sensitizers
15 PPAR- γ, α and δ activation
(Peroxisome Proliferator-Activated Receptor gamma, alpha and delta activators)
Insulin Sensitizers
16 Natural compounds improving Insulin Sensitivity Insulin Sensitizers
17 Natural compounds showing Insulinotrophic effect Insulinotropic effect
18 Natural compounds for other diabetes related issues
(Natural compounds showing Antioxidant potential/reducing inflammation/improving Hormonal imbalance/showing Hypo-lipidemic property/showing Anti-adipogenic activity)
Overcoming other issues related to diabetes '
19 SGLT2 inhibitors Sodium-Glucose Linked Transporter 2 inhibition